PATHOLOGICAL MINERALIZATION

Our main research interest is the process of calcification in soft tissues as a consequence of difference diseases as cardiovascular diseases, cancer, and Alzheimer's disease.

For the most up-to-date list go here.

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2020

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• Tsolaki E, Csincsik L, Xue J, Lengyel I, Bertazzo S (2020) Association of cellular and subcellular calcification with phosphorylated tau in the brains of Alzheimer’s disease patients bioRxiv doi:

• Tsolaki E, Doran W, Magnani L, Olivo A, Herrmann IK, Bertazzo S (2020). Invasive breast tumors are characterized by the presence of crystalline nanoparticles bioRxiv doi:

• Rogers, M. A., Buffolo, F., Schlotter, F., Atkins, S. K., Lee, L. H., Halu, A., . . . Aikawa, E. (2020). Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Science advances, 6 (38). doi:10.1126/sciadv.abb1244

2019

• Anthis, A. H. C., Tsolaki, E., Didierlaurent, L., Staubli, S., Zboray, R., Neels, A., . . . Herrmann, I. K. (2019). Nano-analytical characterization of endogenous minerals in healthy placental tissue: Mineral distribution, composition and ultrastructure. Analyst, 144 (23), 6850-6857. doi:10.1039/c9an01312a

• Tsolaki, E., & Bertazzo, S. (2019). Pathological Mineralization: The Potential of Mineralomics. Materials (Basel), 12 (19). doi:10.3390/ma12193126

2018

• Tan, A. C. S., Pilgrim, M. G., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., . . . Curcio, C. A. (2018). Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration. Science Translational Medicine, 10 (466), ARTN eaat4544. doi:10.1126/scitranslmed.aat4544

• Wald, D. S., Tsolaki, E., Bestwick, J. P., & Bertazzo, S. (2018). Scanning electron microscopy for blood micro-crystals in aortic stenosis patients. PLoS ONE, 13 (8). doi:10.1371/journal.pone.0202282 

2017

• van Engeland, N. C. A., Bertazzo, S., Sarathchandra, P., McCormack, A., Bouten, C. V. C., Yacoub, M. H., . . . Latif, N. (2017). Aortic calcified particles modulate valvular endothelial and interstitial cells. Cardiovascular Pahotlogy, 28, 36-45.

•  Bertazzo, S., & Gentleman, E. (2017). Aortic valve calcification: a bone of contention. European Heart Journal, 38 (16), 1189. ​ ​

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• You, A. Y. F., Bergholt, M. S., St-Pierre, J. -. P., Kit-Anan, W., Pence, I. J., Chester, A. H., . . . Stevens, M. M. (2017). Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta. Science advances, 3 (12), e1701156.

2016

• Bertazzo, S. (2016). Cardiovascular calcification and hard sciences: a solid match [Digital scholarly resource]. Retrieved from http://isacb.org/scientific-profile-by-sergio-bertazzo.

• Krohn, J. B., Hutcheson, J. D., Martinez-Martinez, E., Irvin, W. S., Bouten, C. V. C., Bertazzo, S., . . . Aikawa, E. (2016). Discoidin Domain Receptor-1 Regulates Calcific  Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response  via Transforming Growth Factor-beta Signaling. ArteriosclerosisThrombosis and Vascular Biology, 36 (3), 525-533.

- Selected for front cover

• Hutcheson, J. D., Goettsch, C., Bertazzo, S., Maldonado, N., Ruiz, J. L., Goh, W., . . . Aikawa, E. (2016). Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nature Materials, 15 (3), 335.

•  Agarwal, S., & Bertazzo, S. (2016). New paradigms in cardiovascular calcification. Comptes Rendus Chimie, 19 (11-12), 1605-1609.

2015

• Bertazzo, S. (2015). Bio-medical physical sciences – a personal perspective on interdisciplinary research [Digital scholarly resource]. Retrieved from http://www.materialstoday.com/biomaterials/comment/biomedical-physical-sciences-a-perspective/.

• Bertazzo, S. (2015). Biomineralization. Seminars in Cell and Developmental Biology, 46, 1.

• Bazin, D., Jouanneau, C., Bertazzo, S., Sandt, C., Dessombz, A., Réfrégiers, M., . . . Daudon, M. (2015). Combining field effect scanning electron microscopy, deep UV fluorescence, Raman, classical and synchrotron radiation Fourier transform Infra-Red Spectroscopy in the study of crystal-containing kidney biopsies. Comptes Rendus Chimie, 19 (11-12), 1439-1450.

• Kapustin, A. N., Kalinina, N., Lopatina, T., Davidson, S. M., Iraci, N., Tamkovich, S., . . . Tkachuk, V. (2015). UK-Russia researcher links workshop: Extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1-5 march 2015. Journal of Extracellular Vesicles, 4 (2015), 1-3.

• Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., . . . Shanahan, C. M. (2015). Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion. Circulation Research, 116 (8), 1312-1323.

2014

• Bertazzo, S., Steele, J. A. M., Chester, A. H., Yacoub, M. H. et al  (2014). Cardiovascular calcification violet pearl. The Lancet, 384 (9950), 1294.

• Moore, H. M., Willenberg, T., Coleridge-Smith, P., Chiappini, C., Bertazzo, S. et al (2014). The effects of detergent sclerosants on white blood cells. British Journal of Surgery, 101, 29. WILEY-BLACKWELL.

• Chester, A. H., El-Hamamsy, I., Butcher, J. T., Latif, N., Bertazzo, S., & Yacoub, M. H. (2014). The living aortic valve: From molecules to function. Global Cardiology Science and Practice, 2014 (1), 11.

- Selected for Front Cover

2013

• Bertazzo, S., Gentleman, E., Cloyd, K. L., Chester, A. H., Yacoub, M. H. et al (2013). Nano-analytical electron microscopy reveals fundamental insights into human

       cardiovascular tissue calcification. Nature Materials, 12 (6), 576-583.

- Selected for front cover

- Featured in Nature Materials News & Views

- ACS Chemical & Engineering News

- Materials 360 online