PATHOLOGICAL MINERALIZATION

Cardiovascular Calcification: Our main research interest is the process of calcification in the cardiovascular system, present at the end stage of several cardiovascular diseases and which either directly or indirectly contributes to over 17 million deaths per year according to the UN.

2018

• Tan, A. C. S., Pilgrim, M. G., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., . . . Curcio, C. A. (2018). Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration. Science Translational Medicine, 10 (466), ARTN eaat4544. doi:10.1126/scitranslmed.aat4544

• Wald, D. S., Tsolaki, E., Bestwick, J. P., & Bertazzo, S. (2018). Scanning electron microscopy for blood micro-crystals in aortic stenosis patients. PLoS ONE, 13 (8). doi:10.1371/journal.pone.0202282 

2017

• van Engeland, N. C. A., Bertazzo, S., Sarathchandra, P., McCormack, A., Bouten, C. V. C., Yacoub, M. H., . . . Latif, N. (2017). Aortic calcified particles modulate valvular endothelial and interstitial cells. Cardiovascular Pahotlogy, 28, 36-45.

•  Bertazzo, S., & Gentleman, E. (2017). Aortic valve calcification: a bone of contention. European Heart Journal, 38 (16), 1189. ​ ​

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• You, A. Y. F., Bergholt, M. S., St-Pierre, J. -. P., Kit-Anan, W., Pence, I. J., Chester, A. H., . . . Stevens, M. M. (2017). Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta. Science advances, 3 (12), e1701156.

2016

• Bertazzo, S. (2016). Cardiovascular calcification and hard sciences: a solid match [Digital scholarly resource]. Retrieved from http://isacb.org/scientific-profile-by-sergio-bertazzo.

• Krohn, J. B., Hutcheson, J. D., Martinez-Martinez, E., Irvin, W. S., Bouten, C. V. C., Bertazzo, S., . . . Aikawa, E. (2016). Discoidin Domain Receptor-1 Regulates Calcific  Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response  via Transforming Growth Factor-beta Signaling. ArteriosclerosisThrombosis and Vascular Biology, 36 (3), 525-533.

- Selected for front cover

• Hutcheson, J. D., Goettsch, C., Bertazzo, S., Maldonado, N., Ruiz, J. L., Goh, W., . . . Aikawa, E. (2016). Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nature Materials, 15 (3), 335.

•  Agarwal, S., & Bertazzo, S. (2016). New paradigms in cardiovascular calcification. Comptes Rendus Chimie, 19 (11-12), 1605-1609.

2015

• Bertazzo, S. (2015). Bio-medical physical sciences – a personal perspective on interdisciplinary research [Digital scholarly resource]. Retrieved from http://www.materialstoday.com/biomaterials/comment/biomedical-physical-sciences-a-perspective/.

• Bertazzo, S. (2015). Biomineralization. Seminars in Cell and Developmental Biology, 46, 1.

• Bazin, D., Jouanneau, C., Bertazzo, S., Sandt, C., Dessombz, A., Réfrégiers, M., . . . Daudon, M. (2015). Combining field effect scanning electron microscopy, deep UV fluorescence, Raman, classical and synchrotron radiation Fourier transform Infra-Red Spectroscopy in the study of crystal-containing kidney biopsies. Comptes Rendus Chimie, 19 (11-12), 1439-1450.

• Kapustin, A. N., Kalinina, N., Lopatina, T., Davidson, S. M., Iraci, N., Tamkovich, S., . . . Tkachuk, V. (2015). UK-Russia researcher links workshop: Extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1-5 march 2015. Journal of Extracellular Vesicles, 4 (2015), 1-3.

• Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., . . . Shanahan, C. M. (2015). Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion. Circulation Research, 116 (8), 1312-1323.

2014

• Bertazzo, S., Steele, J. A. M., Chester, A. H., Yacoub, M. H. et al  (2014). Cardiovascular calcification violet pearl. The Lancet, 384 (9950), 1294.

• Moore, H. M., Willenberg, T., Coleridge-Smith, P., Chiappini, C., Bertazzo, S. et al (2014). The effects of detergent sclerosants on white blood cells. British Journal of Surgery, 101, 29. WILEY-BLACKWELL.

• Chester, A. H., El-Hamamsy, I., Butcher, J. T., Latif, N., Bertazzo, S., & Yacoub, M. H. (2014). The living aortic valve: From molecules to function. Global Cardiology Science and Practice, 2014 (1), 11.

- Selected for Front Cover

2013

• Bertazzo, S., Gentleman, E., Cloyd, K. L., Chester, A. H., Yacoub, M. H. et al (2013). Nano-analytical electron microscopy reveals fundamental insights into human

       cardiovascular tissue calcification. Nature Materials, 12 (6), 576-583.

- Selected for front cover

- Featured in Nature Materials News & Views

- ACS Chemical & Engineering News

- Materials 360 online