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Our main research interest is the process of calcification in soft tissues as a consequence of various diseases, including cardiovascular diseases, cancer and Alzheimer's disease.



For the most up-to-date list go here.








  • Tsolaki E, Csincsik L, Xue J, Lengyel I, Bertazzo S (2020) Association of cellular and subcellular calcification with phosphorylated tau in the brains of Alzheimer’s disease patients bioRxiv doi:

  • Tsolaki E, Doran W, Magnani L, Olivo A, Herrmann IK, Bertazzo S (2020). Invasive breast tumors are characterized by the presence of crystalline nanoparticles bioRxiv doi:

  • Rogers, M. A., Buffolo, F., Schlotter, F., Atkins, S. K., Lee, L. H., Halu, A., . . . Aikawa, E. (2020). Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Science Advances, 6 (38). doi:10.1126/sciadv.abb1244


  • Anthis, A. H. C., Tsolaki, E., Didierlaurent, L., Staubli, S., Zboray, R., Neels, A., . . . Herrmann, I. K. (2019). Nano-analytical characterization of endogenous minerals in healthy placental tissue: Mineral distribution, composition and ultrastructure. Analyst, 144 (23), 6850-6857. doi:10.1039/c9an01312a

  • Tsolaki, E., & Bertazzo, S. (2019). Pathological Mineralization: The Potential of Mineralomics. Materials (Basel), 12 (19). doi:10.3390/ma12193126


  • Loaiza, S., Ferreira, S. A., Chinn, T. M., Kirby, A., Tsolaki, E., Dondi, C., . . . Auner, H. W. (2018). An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties. Biomaterials, 183, 102-113. doi:10.1016/j.biomaterials.2018.08.041

  • Highlighted publicationTan, A. C. S., Pilgrim, M. G., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., . . . Curcio, C. A. (2018). Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration. SCIENCE TRANSLATIONAL MEDICINE, 10 (466), ARTN eaat4544. doi:10.1126/scitranslmed.aat4544

  • Tan, A. C. S., Pilgrim, M., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., . . . Curcio, C. A. (2018). Clinical and nano-analytical imaging identify calcified nodules as progression markers for age-related macular degeneration. Presented at: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO).

  • Wald, D. S., Tsolaki, E., Bestwick, J. P., & Bertazzo, S. (2018). Scanning electron microscopy for blood micro-crystals in aortic stenosis patients. PLoS ONE, 13 (8). doi:10.1371/journal.pone.0202282






  • Krohn, J. B., Hutcheson, J. D., Martinez-Martinez, E., Irvin, W. S., Bouten, C. V. C., Bertazzo, S., . . . Aikawa, E. (2016). Discoidin Domain Receptor-1 Regulates Calcific  Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response  via Transforming Growth Factor-beta Signaling. ArteriosclerosisThrombosis and Vascular Biology, 36 (3), 525-533.

- Selected for front cover






  • Bertazzo, S. (2015). Biomineralization. Seminars in Cell and Developmental Biology, 46, 1.








- Selected for Front Cover



       cardiovascular tissue calcification. Nature Materials, 12 (6), 576-583.

- Selected for front cover

- Featured in Nature Materials News & Views

- ACS Chemical & Engineering News

- Materials 360 online


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