
PATHOLOGICAL
CALCIFICATION
Our main research interest is the process of calcification in soft tissues as a consequence of various diseases, including cardiovascular diseases, cancer and Alzheimer's disease.
PUBLICATIONS
For the most up-to-date list go here.
2024
-
Bruch's membrane calcification in pseudoxanthoma elasticum: comparing histopathology and clinical imaging. S Risseeuw, MG Pilgrim, S Bertazzo, CN Brown, L Csincsik, S Fearn, ... Ophthalmology Science 4 (2), 100416
-
Stromal cells regulate mechanics of tumour spheroid. A Agrawal, S Lasli, Y Javanmardi, D Coursier, A Micalet, S Watson, ... Materials Today Bio 23, 100821
2023
-
Multiscale multimodal characterization and simulation of structural alterations in failed bioprosthetic heart valves. E Tsolaki, P Corso, R Zboray, J Avaro, C Appel, M Liebi, S Bertazzo, ... Acta biomaterialia 169, 138-154
-
68Ga-bisphosphonates for the imaging of extraosseous calcification by positron emission tomography. GP Keeling, F Baark, OL Katsamenis, J Xue, PJ Blower, S Bertazzo, ... Scientific Reports 13 (1), 14611
-
A histopathological correlation of Bruch’s membrane calcification in pseudoxanthoma elasticum with clinical retinal imaging. I Lengyel, S Risseeuw, M Pilgrim, C Brown, L Csincsik, S Fearn, ... Investigative Ophthalmology & Visual Science 64 (8), 2311-2311
-
Endothelium and subendothelial matrix mechanics modulate cancer cell transendothelial migration. Y Javanmardi, A Agrawal, A Malandrino, S Lasli, M Chen, S Shahreza, ... Advanced Science 10 (16), 2206554
-
Inter-Organ Communication in Homeostasis and Disease: Epidermal growth factor receptor inhibition prevents vascular calcifying extracellular vesicle biogenesis. AB Nik, HH Ng, SK Ashbrook, P Sun, F Iacoviello, PR Shearing, ... American Journal of Physiology-Heart and Circulatory Physiology 324 (4), H553
-
Epidermal growth factor receptor inhibition prevents vascular calcifying extracellular vesicle biogenesis. A Bakhshian Nik, HH Ng, SK Ashbrook, P Sun, F Iacoviello, PR Shearing, ... American Journal of Physiology-Heart and Circulatory Physiology 324
2022
-
Alizarin Red fluorescence imaging for nano calcification. CV Coralli, J Xue, AH Chester, S Bertazzo bioRxiv, 2022.07. 28.501840
-
The time-dependent role of bisphosphonates on atherosclerotic plaque calcification. A Bakhshian Nik, HH Ng, M Garcia Russo, F Iacoviello, PR Shearing, ... Journal of Cardiovascular Development and Disease 9 (6), 168
-
Density-Dependent Color Scanning Electron Microscopy (DDC-SEM) for calcified tissue and pathological calcification. E Tsolaki, AH Chester, S Bertazzo. bioRxiv, 2022.05. 06.490880
-
Nuclear and cellular, micro and nano calcification in Alzheimer's disease patients and correlation to phosphorylated Tau. E Tsolaki, L Csincsik, J Xue, I Lengyel, S Bertazzo. Acta biomaterialia 143, 138-144
2021
-
Engineered in vitro models for pathological calcification: routes toward mechanistic understanding. E Radvar, G Griffanti, E Tsolaki, S Bertazzo, SN Nazhat, O Addison, ... Advanced NanoBiomed Research 1 (8), 2100042
-
Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model. JL Ruiz, JD Hutcheson, L Cardoso, A Bakhshian Nik, ... Proceedings of the National Academy of Sciences 118 (14), e1811725118
-
Annexin A1–dependent tethering promotes extracellular vesicle aggregation revealed with single–extracellular vesicle analysis. MA Rogers, F Buffolo, F Schlotter, SK Atkins, LH Lee, A Halu, MC Blaser, ... Science Advances 6 (38), eabb1244
2020
-
Tsolaki E, Csincsik L, Xue J, Lengyel I, Bertazzo S (2020) Association of cellular and subcellular calcification with phosphorylated tau in the brains of Alzheimer’s disease patients bioRxiv doi: https://doi.org/10.1101/2020.06.15.148353
-
Tsolaki E, Doran W, Magnani L, Olivo A, Herrmann IK, Bertazzo S (2020). Invasive breast tumors are characterized by the presence of crystalline nanoparticles bioRxiv doi:https://doi.org/10.1101/2020.04.29.067660
-
Rogers, M. A., Buffolo, F., Schlotter, F., Atkins, S. K., Lee, L. H., Halu, A., . . . Aikawa, E. (2020). Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Science Advances, 6 (38). doi:10.1126/sciadv.abb1244
2019
-
Anthis, A. H. C., Tsolaki, E., Didierlaurent, L., Staubli, S., Zboray, R., Neels, A., . . . Herrmann, I. K. (2019). Nano-analytical characterization of endogenous minerals in healthy placental tissue: Mineral distribution, composition and ultrastructure. Analyst, 144 (23), 6850-6857. doi:10.1039/c9an01312a
-
Tsolaki, E., & Bertazzo, S. (2019). Pathological Mineralization: The Potential of Mineralomics. Materials (Basel), 12 (19). doi:10.3390/ma12193126
2018
-
Loaiza, S., Ferreira, S. A., Chinn, T. M., Kirby, A., Tsolaki, E., Dondi, C., . . . Auner, H. W. (2018). An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties. Biomaterials, 183, 102-113. doi:10.1016/j.biomaterials.2018.08.041
-
Highlighted publicationTan, A. C. S., Pilgrim, M. G., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., . . . Curcio, C. A. (2018). Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration. SCIENCE TRANSLATIONAL MEDICINE, 10 (466), ARTN eaat4544. doi:10.1126/scitranslmed.aat4544
-
Tan, A. C. S., Pilgrim, M., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., . . . Curcio, C. A. (2018). Clinical and nano-analytical imaging identify calcified nodules as progression markers for age-related macular degeneration. Presented at: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO).
-
Wald, D. S., Tsolaki, E., Bestwick, J. P., & Bertazzo, S. (2018). Scanning electron microscopy for blood micro-crystals in aortic stenosis patients. PLoS ONE, 13 (8). doi:10.1371/journal.pone.0202282
2017
-
van Engeland, N. C. A., Bertazzo, S., Sarathchandra, P., McCormack, A., Bouten, C. V. C., Yacoub, M. H., . . . Latif, N. (2017). Aortic calcified particles modulate valvular endothelial and interstitial cells. Cardiovascular Pahotlogy, 28, 36-45.
-
Bertazzo, S., & Gentleman, E. (2017). Aortic valve calcification: a bone of contention. European Heart Journal, 38 (16), 1189.
-
You, A. Y. F., Bergholt, M. S., St-Pierre, J. -. P., Kit-Anan, W., Pence, I. J., Chester, A. H., . . . Stevens, M. M. (2017). Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta. Science advances, 3 (12), e1701156.
2016
-
Bertazzo, S. (2016). Cardiovascular calcification and hard sciences: a solid match [Digital scholarly resource]. Retrieved from http://isacb.org/scientific-profile-by-sergio-bertazzo.
-
Krohn, J. B., Hutcheson, J. D., Martinez-Martinez, E., Irvin, W. S., Bouten, C. V. C., Bertazzo, S., . . . Aikawa, E. (2016). Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-beta Signaling. ArteriosclerosisThrombosis and Vascular Biology, 36 (3), 525-533.
- Selected for front cover
-
Hutcheson, J. D., Goettsch, C., Bertazzo, S., Maldonado, N., Ruiz, J. L., Goh, W., . . . Aikawa, E. (2016). Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nature Materials, 15 (3), 335.
-
Agarwal, S., & Bertazzo, S. (2016). New paradigms in cardiovascular calcification. Comptes Rendus Chimie, 19 (11-12), 1605-1609.
2015
-
Bertazzo, S. (2015). Bio-medical physical sciences – a personal perspective on interdisciplinary research [Digital scholarly resource]. Retrieved from http://www.materialstoday.com/biomaterials/comment/biomedical-physical-sciences-a-perspective/.
-
Bertazzo, S. (2015). Biomineralization. Seminars in Cell and Developmental Biology, 46, 1.
-
Bazin, D., Jouanneau, C., Bertazzo, S., Sandt, C., Dessombz, A., Réfrégiers, M., . . . Daudon, M. (2015). Combining field effect scanning electron microscopy, deep UV fluorescence, Raman, classical and synchrotron radiation Fourier transform Infra-Red Spectroscopy in the study of crystal-containing kidney biopsies. Comptes Rendus Chimie, 19 (11-12), 1439-1450.
-
Kapustin, A. N., Kalinina, N., Lopatina, T., Davidson, S. M., Iraci, N., Tamkovich, S., . . . Tkachuk, V. (2015). UK-Russia researcher links workshop: Extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1-5 march 2015. Journal of Extracellular Vesicles, 4 (2015), 1-3.
-
Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., . . . Shanahan, C. M. (2015). Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion. Circulation Research, 116 (8), 1312-1323.
2014
-
Bertazzo, S., Steele, J. A. M., Chester, A. H., Yacoub, M. H. et al (2014). Cardiovascular calcification violet pearl. The Lancet, 384 (9950), 1294.
-
Moore, H. M., Willenberg, T., Coleridge-Smith, P., Chiappini, C., Bertazzo, S. et al (2014). The effects of detergent sclerosants on white blood cells. British Journal of Surgery, 101, 29. WILEY-BLACKWELL.
-
Chester, A. H., El-Hamamsy, I., Butcher, J. T., Latif, N., Bertazzo, S., & Yacoub, M. H. (2014). The living aortic valve: From molecules to function. Global Cardiology Science and Practice, 2014 (1), 11.
- Selected for Front Cover
2013
-
Bertazzo, S., Gentleman, E., Cloyd, K. L., Chester, A. H., Yacoub, M. H. et al (2013). Nano-analytical electron microscopy reveals fundamental insights into human
cardiovascular tissue calcification. Nature Materials, 12 (6), 576-583.
- Selected for front cover
- Featured in Nature Materials News & Views
- ACS Chemical & Engineering News
- Materials 360 online
